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KMID : 0386320000330020067
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Korean Leprosy Bulletin
2000 Volume.33 No. 2 p.67 ~ p.78
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HLA-A, B and DRB1 Genes Related with Susceptibility and Type of Hansen’s Disease
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Chae Gue-Tae
Lee Seong-Beom
Kang Tae-Jin
Kim Jong-Pil
Ko Young-Hoon
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Abstract
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To find out whether the susceptibility to Hansen’s disease are associated with HLA genes, serological and nucleotide typing of HLA-A, B, and DRB1 alleles have been conducted in 301 Hansen’s disease patients[190 Multibacillary cases(MB, LL/BL),
111
Paucibacillary cases(PB, TT/BT) confirmed at the time of diagnosis, almost of them were treated with Multidrug therapy] and 928 healthy controls from a population in Seoul and Northern area of Han River in Kyunggi Province, Korea.
HLA-A30[relative
risk(RR) 1.58, χ2 =4.89, P=0.04] was significantly associated with Hansen’s disease. In contrast to HLA-B27(RR 0.20, χ2=11.34, P=0.0002), which was negatively associated with Hansen’s disease as a whole, in MB and PB separately, HLA-B52(RR
1.97,
χ2
=6.89, P=0.002) and B46(RR 1.63, χ2 =4.84, P=0.04) were significantly increased in Hansen’s disease. DRB1*02 was associated with MB(LL/BL)[RR 1.96, χ2=13.47, P=0.0004] but not with PB(TT/BT). Further works about oligonuceotide typing of DQA,B,
and
DPB1 are ongoing. High resolution study to define DRB1*02 alleles will be performed.
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KEYWORD
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